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Help with weight loss: Herbal active ingredient activates the saturation center in the brain
According to German researchers, an herbal active ingredient from Chinese medicine shows promising results in weight loss. It could possibly be a new treatment option for pathological obesity.
When you consider that being overweight or obese can lead to health problems such as high blood pressure and an increased risk of cardiovascular diseases, such as a heart attack, there are certainly enough reasons to lose those extra pounds. Many try to slim down again through dieting. But a large part of these methods are not suitable for everyday use and experts have been arguing for years about which form of diet is the best. A new weight loss pill that US researchers recently reported may be able to help. Or a herbal ingredient from Chinese medicine. According to German scientists, this activates saturation centers in the brain.
Significant weight loss and improvement in diabetes
The guideline "Prevention and Therapy of Obesity" recommends at least five to ten percent less weight per year for people with pathological obesity, depending on the body mass index (BMI).
But despite numerous diet and lifestyle offers, only a few achieve this goal.
"It would be so important to go below this 'magic limit', since it leads to an improvement in the metabolism and metabolic comorbidities such as type 2 diabetes," explains Dr. A message from Paul Pfluger from the Helmholtz Zentrum München.
The scientist and his team from the Neurobiology Department of Diabetes at Helmholtz Zentrum München have now successfully contributed to the development of new anti-obesity drugs.
The researchers were able to show that the herbal active ingredient Celastrol used in Chinese medicine leads to significant weight loss and an improvement in diabetes in obese mice.
The study results were recently published in the journal "Diabetes".
Active ingredient switches on the feeling of satiety again
The scientists from Munich were able to demonstrate that Celastrol specifically activates saturation centers in the brain, which play a central role in controlling body weight.
"Celastrol reactivates the body's own mechanisms for weight control, which are otherwise subject to obesity," explains Katrin Pfuhlmann, doctoral student and first author of the study.
“Usually, those affected lose their feeling of satiety because the corresponding hormone leptin no longer works. The active ingredient Celastrol that we investigated restores leptin sensitivity and thus saturation, ”says the researcher.
Support patients with sustainable weight loss
In fact, the experts observed a significantly changed eating behavior in the overweight animals.
"The administration of Celastrol resulted in a significantly lower food intake in the mouse model," says study leader Paul Pfluger. "Accordingly, we were able to determine an average loss of around ten percent body weight within a week."
To what extent the findings can also be confirmed in humans is still unclear, according to the authors. But Pfluger is confident: "The saturation hormone leptin works almost identical in humans and mice, so Celastrol has great potential."
Celastrol will not replace the change in dietary habits and living conditions necessary for losing weight, but it could support the patient in his efforts to achieve sustainable weight loss.
"Clinical studies are currently being carried out in the USA, and we are very excited to see the first data," said Pfluger. (ad)