New marker identified: better recognizing and understanding cardiovascular diseases

New marker identified: better recognizing and understanding cardiovascular diseases

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Determine the risk of heart attack, stroke and co. Earlier and more precisely

Cardiovascular diseases are the most common cause of death in Germany. Researchers have now succeeded in identifying a new marker. The knowledge gained could help the risk of such diseases to be determined earlier and more precisely in the future.

More and more deaths from heart disease

According to a report by the German Heart Foundation, the number of deaths from heart disease has risen again. Cardiovascular diseases are another leading cause of death in other countries in the western world. A healthier lifestyle would prevent around every second death, as experts recently reported. German researchers have now gained further new insights into cardiovascular diseases.

Researchers were able to identify new markers

Older people in particular are affected by cardiovascular diseases. In addition to life expectancy, cardiovascular diseases can also severely limit quality of life.

Researchers at the German Institute for Nutritional Research Potsdam-Rehbrücke (DIfE) have now successfully identified a new marker.

Accordingly, the protein chemer provides insights into the partly still unknown mechanisms of the development of the disease and could be used in the future to determine the risk of heart attack, stroke and Co. even earlier and more precisely.

The results of the study were published in the current issue of the "Journal of the American College of Cardiology".

Messenger substance is mainly formed in adipose tissue

As the DIfE explains in a communication, chemerin is a messenger substance (adipokine), which is mainly formed in the adipose tissue as well as in the liver, kidneys and pancreas.

It contributes to the initially identical, undifferentiated cells of the adipose tissue specializing in certain functions and functions for certain tasks.

In addition, Chemerin lures immune cells to injured tissue, which immediately causes inflammation there and fends off infections. The signal protein is therefore part of the body's finely regulated alarm system.

“If the system gets out of joint, there is a risk of arteriosclerosis, heart attack and stroke,” explains Dr. Krasimira Aleksandrova, who studies at DIfE how the interplay between diet, body composition and the immune system influences age-related diseases.

Predict cardiovascular disease risk more accurately

The exact relationships between inflammatory reactions and cardiovascular diseases have not yet been fully elucidated.

To shed more light on the matter, the team led by Aleksandrova analyzed the blood samples from a total of 2,500 men and women. The data were based on the Potsdam EPIC study with over 27,500 study participants.

The scientists observed for the first time that the concentration of chemerin in the blood increased before the onset of heart attacks and strokes.

Chemerin could thus be used in the future as an indicator to more precisely predict the risk of cardiovascular diseases.

"Our results confirm that the chemerin signal protein plays an important role in both inflammatory processes and the development of cardiovascular diseases," said Aleksandrova.

“This track should definitely be followed up. Understanding the precise functions of chemerin could improve the search for new prevention therapies and medicines in the future. ”(Ad)

Author and source information

Video: Heart disease 7, Cardiac markers (February 2023).