Cervical cancer: does a dose of HPV vaccine protect?

Cervical cancer: does a dose of HPV vaccine protect?

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How can women protect themselves from cervical cancer?

Even a single dose of the human papillomavirus (HPV) vaccine appears to be as effective as multiple doses to prevent pre-invasive cervical disease, which can later develop into cervical cancer.

The University of Texas latest study found that a single dose of the human papillomavirus (HPV) vaccine can be used effectively to prevent pre-invasive disease of the cervix. The results of the study were published in the English-language journal of the American Cancer Society (ACS) "Cancer".

HPV can cause cervical cancer

Researchers have recently shown that eleven types of viruses promote cancer. Human papilloma viruses also belonged to this group. New research now suggests that a single dose of the human papillomavirus (HPV) vaccine is as effective as multiple doses to prevent pre-invasive cervical disease. HPV is a common sexually transmitted infection. Prolonged infection with certain types of the virus can cause cervical cancer.

Should young people get vaccinated against HPV?

To prevent infection, the Centers for Disease Control and Prevention (CDC) in America, for example, advise that teenagers under the age of 15 (both boys and girls) should receive two doses of the HPV vaccine.

What dose should be used?

To determine the effectiveness of other dose regimens, University of Texas researchers analyzed data on women ages nine to 26 who were not vaccinated between January 2006 and June 2015 or who received one or more doses of HPV vaccine.

Data from over 133,000 women were evaluated

The investigation included 133,082 women (66,541 vaccinated and 66,541 unvaccinated). In women ages 15 to 19, those who received one, two, or three doses of the HPV vaccine had lower rates of pre-invasive cervical disease than unvaccinated adolescents.

How many participants developed pre-invasive cervical disease?

Within five years, 2.65 percent of unvaccinated adolescents aged 15 to 19 years developed pre-invasive cervical disease, compared to 1.62 percent, 1.99 percent, and 1.86 percent in the one, two, or three group Dosages.

What was the reduced risk from vaccination?

The risk of pre-invasive cervical disease was 36 percent, 28 percent, and 34 percent less in adolescents who received one, two, or three doses than in unvaccinated adolescents.

What impact did age have on results?

However, for the youngest (less than 15 years old) and the oldest age group (20 years and older), the researchers found no significant differences between the vaccinated groups with regard to the risk of pre-invasive cervical disease.

Vaccination leads to long-term protection against cervical cancer

The results of the study show the effects of vaccination at a younger age and its long-term protection against cervical cancer. It is important that parents are informed about the need to vaccinate their children, the researchers report.

Benefits of just one dose of HPV vaccine

If just one dose of the HPV vaccine is sufficient for effective protection, the application of the vaccination would be significantly simplified and would also require less logistics. A dose could be made available to more people and the total costs would also be lower, the study team summarizes. (as)

Author and source information

This text corresponds to the requirements of the medical literature, medical guidelines and current studies and has been checked by medical doctors.


  • MD, MPH Ana M. Rodriguez, MD Burak Zeybek, MD Micah Vaughn, MPH Jordan Westra, PHD Sapna Kaul et al.: Comparison of the long-term impact and clinical outcomes of fewer doses and standard doses of human papillomavirus vaccine in the United States: A database study, in CANCER (Published Feb 10, 2020), Cancer

Video: Dr. Nita Lee on the HPV Vaccine u0026 Cervical Cancer (October 2022).